Cryolys Evolution

Obtaining high-quality, high-yield DNA from a sample requires an optimal homogenization process. Below, our team of scientists shares helpful tips to choose the right homogenization protocol for your DNA extraction

RNA isolation can often be challenging, particularly when working with complex samples. Common difficulties included low yield, low purity, RNA degradation, and DNA contamination. Below, Bertin’s team of scientists have shared best practices for homogenization protocols that allow for successful isolation of high-quality RNA.

Protein extraction is a key step for analytical methods such as Western Blot and enzymatic assays. Below, Bertin’s top scientists have shared best practices to improve your homogenization protocol for a wide range of tissues, including tips to preserve the integrity of the proteins in your samples and achieve optimal yield.

The disruption of samples is the first step in the process of isolation and/or quantification of nucleic acids, proteins, and analytes. For this reason, choosing the right homogenization protocol will have a great impact on the quality and reliability of results for most biological analytical workflows.

PCR is a vital analytical tool for modern biologists. The success of PCR workflows is highly dependent on the quantity, purity, and degree of fragmentation of the DNA. Here, Bertin’s top scientists have presented examples of optimized homogenization protocols to obtain high quality nucleic acids and guarantee the success of your PCR workflow.

The advent of next-generation sequencing techniques (NGS) has dramatically changed the field of biology. Below, Bertin’s team of scientists have introduced optimized sample preparation protocols examples to ensure high quality, high yield nucleic acids for your NGS workflows.

Successfully extracting metabolites is a crucial step in metabolite profiling. Discover here our top scientists’ homogenization protocols for metabolite extraction from a wide range of samples.

Drug extraction is a critical step in pharmaceutical, toxicological, environmental, and food analysis. On this page, our scientists have listed a selection of our best protocols for drug extraction from a wide range of tissues.

Western Blot is a widely used molecular biology technique to detect specific proteins in a sample. On this page, our experts present their tips and tricks to improve your homogenization protocol for Western Blot, as well as a chosen selection of our best application notes on Western Blot.

Mass spectrometry is an essential analytical technique in chemistry and biology. Below our experts share their advice on improving homogenization protocols for mass spectrometry workflows for protein, metabolites, and drug analysis in complex samples.

Chromatography is a laboratory technique to separate, identify, and quantify each component in a sample. Below, our tops experts have shared a selection of our best sample preparation protocols for chromatography workflows.

Soil and environmental analysis often focus on microbiology studies and pollution impact on wildlife. Microorganisms included in a biological matrix are particularly challenging to lyse.

Pharmaceutical research starts with lead molecule identification from a natural or artificial model. In either case, the DMPK or animal toxicology models analysis requires the homogenization of tissues.

Hard tissues such as those from tumors can be particularly difficult to homogenize, and animal models are often used in cancer research. Precellys homogenizer is perfectly adapted to applications of this kind.

Extremely hard samples such as bone, teeth, and hair are common in forensic laboratories. Popular downstream applications include DNA extraction from bone or teeth and drug extraction from hair.

Agronomy research into GMO analysis, food allergies and plant studies, often require grounded hard samples such as seeds, roots or frozen food, which are particularly hard to grind.

Microorganism studies are critical as they are used for bio-production and health research. They are difficult to lyse due to their thick cell wall, which makes nucleic acid extraction difficult.