Cryolys Evolution - Bertin Technologies


Cryolys Evolution

Cryolys Evolution is a patented cooling system compatible with the Precellys Evolution tissue homogenizer. It prevents thermo-sensitive samples from heat degradation during homogenization process.

The Cryolys Evolution is the cooling system specially developped for Precellys Evolution tissue homogenizer. Based on dry ice sublimation, it enhances the efficiency of molecular extraction, resulting in premium quality analysis, maintaining the desired temperature between 0 and 10°C before and during the tissue homogenization.

The Cryolys Evolution unit must run off Precellys Evolution and may be purchased separately.

The Precellys Evolution tissue homogenizer software monitors the temperature for fully accurate results. It allows an optimal protection of the sensitive molecules from heat degradation. Cryolys Evolution is the ideal solution when working on native state thermo-sensitive molecules such as active RNA, siRNA, metabolites, enzymes, proteins while getting an hight yield extraction.

Watch Cryolys Evolution in action,
the most efficient cooling unit for tissue homogenizer!

• Efficient cooling: before, during and after processing
• No need for compressed air or power supply
• Accurate temperature monitored by Precellys® Evolution homogenizer software
• Minimal bench space

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Discover the key steps of Cryogrinding with Cryolys

Cryogrinding is a key technique to process sensitive samples preparation without adding buffer or external components. To avoid degradation, ultra-low temperatures must be used in order to preserve the sensitive molecules they contain while making them easier to handle.

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Cryolys Evolution

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  • 1,5kg/3,3lb of dry ice

Space requirement:

  • Height over bench: 70cm
  • Depth of the bench: 70cm

Dry ice consumption:

  • 1,5kg/3,3lb for 30 min (run time)


  • Full unit: 2,6kg/5,7lb
  • Detachable cooling module: 1,3kg/2,8lb


  • Length: 335mm
  • Width: 335mm
  • Height: 100mm


  • Unit plugged to a Precellys Evolution


  • <60dB


  • CE

Catalog number:

  • P000671-CLYS2-A.0  Cryolys Evolution
  • K002198-PEVO0-A.0 Combo Precellys Evolution + Cryolys Evolution


Download the user guide

Easy to install:

  • Powered and controlled by Precellys Evolution, no compressed air required

Easy to use:

  • Precellys Evolution software automatically monitors the protocol run

Fast and accurate:

  • Target temperature reached in less than 2minutes and fully monitored

The Cryolys technology presents two main features:

1- The cooling patented technology of Cryolys Evolution is based on the cold generated during dry ice sublimation by ambiant air without frost apparition. The ambiant airflow in contact with dry ice is getting immediately cooled and is injected in the tubes area.


2- This airflow is adjusted depending on the desired temperature and the monitored temperature ensuring protocol’s accuracy and therefore fragile molecules protection during the homogenizationprocess.

Frequently Asked Questions

  • How can I prevent heat generation and keep a constant temperature of 4°C (+39°F)?
  • Can the Precellys be used in a cold room?
  • Are there specific recommended actions for Precellys® maintenance?


Read the answers and see the other questions

Reasons to choose Cryolys Evolution

Easy to install:Powered and controlled by Precelly Evolution, no compressed air required

Easy to use: Precellys Evolution software automatically monitors the protocol run

Fast and accurate: target temperature reached in less than 2minutes and fully monitored

User-Friendly: Cryolys Evolution is free standing


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