[PUBLICATION PRECELLYS] Icariin ameliorates estrogen-deficiency induced bone loss by enhancing IGF-I signaling via its crosstalk with non-genomic ERa signaling - Bertin Technologies

[PUBLICATION PRECELLYS] Icariin ameliorates estrogen-deficiency induced bone loss by enhancing IGF-I signaling via its crosstalk with non-genomic ERa signaling

pingZhoua#Christina Chui-WaPoona#Ka-YingWongaSisiCaoaXiaoliDongaYanZhangacMan-SauWongab
Sources: https://www.sciencedirect.com/science/article/pii/S0944711320302440?casa_token=MrM8I8dj8LMAAAAA:A6oJ2lJmNGFlzmFEZKW29U_Xo2Esr0RsWL8zKqeZTCQ7cvUeUulyaoMYmlL-ODoO4EovV3Ng
Phytomedecine

Abstract

Background

Rapid, non-genomic estrogen receptor (ER) signaling plays an integral role in mediating the tissue selective properties of ER modulators. Icariin, a bone bioactive flavonoid, has been reported to selectively activate non-genomic ERa signaling in in vitro and in vivo studies.
Purpose

The mechanisms underlying the estrogen-like bone protective effects of icariin are not fully understood, especially those that are related to insulin-like growth factor I (IGF-1) signaling. The bone protective effects of icariin were investigated in female mature ovariectomized (OVX) rats and the signaling of IGF-IR- ERa cross-talk was determined in osteoblastic cells.

Sample type

Rat bone samples

Target

RNA Extraction

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