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Researchers have made some fascinating discoveries about the treatment of migraine. Calcitonin gene-related peptide (CGRP) has long been associated with the development of migraine. Monoclonal antibodies (mAbs) targeting the CGRP pathway, including erenumab, galcanezumab and fremanezumab, have shown promise in clinical trials and real-life studies. Initially, the European Headache Federation recommended treatment with CGRP(-R) mAbs […]

LEAP-2 helps regulate inflammatory responses and maintain microbiota balance. Discover the high performance of LEAP-2, the new ELISA kit from Bertin Bioregeant.

Histamine is an organic compound that plays a major role in the development of allergies. Most allergic diseases are triggered by the interaction between an allergen and allergen-specific antibodies present in mast cells, multifunctional bone marrow-derived tissue-dwelling cells responsible for histamine production. This interaction leads to the degranulation of these cells, which provokes the release […]

Atopic dermatitis (AD) is an inflammatory skin disease causing itching and redness. CGRP (calcitonin gene-related peptide) is a neuropeptide that plays an important role in pain and inflammation. Recent studies have suggested that CGRP may be involved in the pathogenesis of atopic dermatitis. Indeed, an increase in CGRP expression has been observed in skin with […]

Preparing high-quality emulsions is a critical step to successfully generate specific antibodies. The generation of antigen-specific antibodies is especially important since it involves the injection of an immunogenic antigen-adjuvant emulsion in animals at defined time intervals. The two-syringe technique is widely employed as the standard method for emulsion preparation. Despite its popularity, this method has […]

Bertin Bioreagent offers two kits to extract DNA and total RNA from animal tissues. These kits are part of a complete sample preparation workflow that starts with tissue homogenization using Precellys instruments and whose quality has been validated by Bertin Health & Life Sciences R&D team. DNA extraction is a critical step in molecular biology […]

Intravenous immunoglobulin (IVIG) is known for its anti-inflammatory effects and is commonly used to treat auto-immune and systemic inflammatory diseases. Basophils are a type of white blood cells that are responsible for inflammatory reactions during the immune response and produce inflammatory mediators such as histamine and serotonin. Recently, it has been reported that, the anti-inflammatory […]

20-Hydroxyecdysone (20-HE) is known as the insect moulting hormone. It is part of the ecdysteroids family. Combined with the juvenile hormone (JH), 20-HE plays a key role in the growth, development, metamorphosis, and reproduction of arthropods (i.e. invertebrates such as insects, crustaceans, arachnids, etc.). Little is known about the function of ecdysteroids in vertebrates. There […]

Stem cells can develop into multiple cell types through a process called differentiation. The cellular form of prion protein (PrPC) has been reported to be involved in various cellular pathways and could also have a role in the differentiation of stem cells into neurons. Several studies have shown that the prion protein PrPC may be […]

Irritable bowel syndrome (IBS) is a common condition arising from genetic and environmental factors. It is characterized by a group of symptoms affecting the digestive system, including abdominal discomfort and altered bowel movements. Little is known about the environmental triggers for IBS. The symptoms might result from an altered immune response. Aluminum is a common […]