Application Push

Researchers have made some fascinating discoveries about the treatment of migraine. Calcitonin gene-related peptide (CGRP) has long been associated with the development of migraine. Monoclonal antibodies (mAbs) targeting the CGRP pathway, including erenumab, galcanezumab and fremanezumab, have shown promise in clinical trials and real-life studies. Initially, the European Headache Federation recommended treatment with CGRP(-R) mAbs […]

Intravenous immunoglobulin (IVIG) is known for its anti-inflammatory effects and is commonly used to treat auto-immune and systemic inflammatory diseases. Basophils are a type of white blood cells that are responsible for inflammatory reactions during the immune response and produce inflammatory mediators such as histamine and serotonin. Recently, it has been reported that, the anti-inflammatory […]

Micro RNAs are small naturally occurring non-coding ribonucleic acids, with sizes between 18 and 40 nucleotides (nts). Found in plants, animals and viruses, they have been proven to play a significant role in RNA silencing and the regulation of gene expression. As a result, interest in smaller RNA species, such as miRNA, has increased. In […]

Precellys solutions replace time-consuming manual grinding & preserve metabolite properties Cryogenic grinding is an efficient method for mechanic tissue disruption. Precellys transforms solid & resilient tissue samples into powder in only a few seconds, and homogenizes tissues at low temperature, preventing the chemical transformation of unstable metabolites. In this new application note, discover the best […]

The blood-brain barrier (BBB) plays a critical role regulating the homeostasis in the central nervous system and defending it against toxins or microorganisms. The endothelium forming the BBB can be modulated by different stimulus such as inflammatory mediators. In this application note, discover how you can establish an in vivo model for the assessment of […]

The advent of next-generation sequencing techniques (NGS) has revolutionized the landscape of biology, allowing scientists to deepen their understanding of many diseases such as cancer. NGS workflows generally begin with a sample preparation step, whose success is crucial to ensure reliable sequencing results. An efficient and uniform homogenization is needed to obtain an adequate quantity […]

Microorganisms, like bacteria, fungi, archaea, algae, protozoa, and viruses, known as microbes, play a critical role in many different phenomena. They are involved in climate change, nutrient cycling, biodegradation and diseases. In biotechnology, microbes can be used in a wide range of fields, such as the pharmaceutical industry to produce drugs, the environmental sector to […]

With more than 300 publications referring to Precellys, this equipment is recognized in the scientific world as reference for optimal molecules’ extraction, in compliance with the increasingly used identification techniques. Numerous studies quote Precellys’ product range, demonstrating not only its efficiency for laboratory tasks but also its added-value for accurate researches. For example, the 7mL Lysing […]

Over the last years, biology techniques have considerably evolved, whether it be with mass spectrometry protein analysis or multiplex protein analysis and nucleic acids with qPCR, or sequencing… All those techniques have reached sensitivity levels never reached before. In parallel to increased sensitivity, cost per point has become lower for all laboratories, broadening the possibilities […]

Protein analysis is a crucial step in many research projects. The techniques linked to this field are evolving relatively fast and require high quality samples because the analysis’ sensitivity provided by modern equipment is constantly getting more precise. Therefore, extracting proteins in the best conditions and ensuring their original state preservation is essential. During the […]