Application Push Archives - Bertin Technologies

New Insights into Migraine Treatment: CGRP Levels After Monoclonal Antibody Cessation

Mathilde De Guerry — Mon, 03 Jun 2024 09:50:13 +0000

Researchers have made some fascinating discoveries about the treatment of migraine. Calcitonin gene-related peptide (CGRP) has long been associated with the development of migraine. Monoclonal antibodies (mAbs) targeting the CGRP pathway, including erenumab, galcanezumab and fremanezumab, have shown promise in clinical trials and real-life studies. Initially, the European Headache Federation recommended treatment with CGRP(-R) mAbs […]

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Evaluation of histamine concentrations in human basophil culture supernatants

Margaux Leger — Thu, 30 Mar 2023 13:09:41 +0000

Intravenous immunoglobulin (IVIG) is known for its anti-inflammatory effects and is commonly used to treat auto-immune and systemic inflammatory diseases. Basophils are a type of white blood cells that are responsible for inflammatory reactions during the immune response and produce inflammatory mediators such as histamine and serotonin. Recently, it has been reported that, the anti-inflammatory […]

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Micro RNA & total RNA purification from liver tissue

Margaux Leger — Thu, 16 Mar 2023 15:46:22 +0000

Micro RNAs are small naturally occurring non-coding ribonucleic acids, with sizes between 18 and 40 nucleotides (nts). Found in plants, animals and viruses, they have been proven to play a significant role in RNA silencing and the regulation of gene expression. As a result, interest in smaller RNA species, such as miRNA, has increased. In […]

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Radiation monitoring on air quality around cities

Anne-Claire Hello — Fri, 16 Sep 2022 08:49:18 +0000

Following the Chernobyl disaster in 1986, French authorities decided to equip air quality monitoring networks near nuclear power plants with a reliable and independent radioactive measurement system. In 2015, the question of replacing the air monitoring beacons arose. The Hauts-de-France Region and the Urban Community of Dunkirk wanted Atmo Hauts-de-France to take on this case. […]

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[Application note] Enhance new approaches in environmental monitoring

Margaux Leger — Tue, 31 May 2022 07:44:34 +0000

Considering previous nuclear disasters in the last thirty years (Chernobyl, Fukushima), authorities had to realize that there was very low knowledge about the actual level and dispersion of radiation. Consequently after those events, many nuclear power plants and surveillance authorities had to upgrade and strengthen their measurement networks to comply with a similar catastrophe scenario. […]

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[App Note] How to perform efficient tissue homogenization by Cryogrinding?

hello@bertin.fr — Tue, 12 Jan 2021 14:29:45 +0000

Precellys solutions replace time-consuming manual grinding & preserve metabolite properties Cryogenic grinding is an efficient method for mechanic tissue disruption. Precellys transforms solid & resilient tissue samples into powder in only a few seconds, and homogenizes tissues at low temperature, preventing the chemical transformation of unstable metabolites. In this new application note, discover the best […]

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New application note: Analyse brain tissues with Precellys

Anne-Claire Hello — Tue, 15 Dec 2020 17:08:57 +0000

The blood-brain barrier (BBB) plays a critical role regulating the homeostasis in the central nervous system and defending it against toxins or microorganisms. The endothelium forming the BBB can be modulated by different stimulus such as inflammatory mediators. In this application note, discover how you can establish an in vivo model for the assessment of […]

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[WHITE PAPER] Optimized homogenization protocols for NGS workflows

Anne-Claire Hello — Fri, 18 Sep 2020 13:48:36 +0000

The advent of next-generation sequencing techniques (NGS) has revolutionized the landscape of biology, allowing scientists to deepen their understanding of many diseases such as cancer. NGS workflows generally begin with a sample preparation step, whose success is crucial to ensure reliable sequencing results. An efficient and uniform homogenization is needed to obtain an adequate quantity […]

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New application note: Continuous measurement of radon concentration in water with Radon Exchange Module 1

hello@bertin.fr — Wed, 11 Sep 2019 08:26:31 +0000

The ALARA precautionary principle (As Low As Reasonably Possible) is the golden rule of radiation protection in the field of Risk Analysis science. This rule is applied to the exposure of individuals to radioactivity; this exposure must be low to be protected against health risks. Prolonged exposure to high-level ionizing radiation, such as radon gas, […]

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Best practices in microorganisms sample preparation with Precellys homogenizers | Download the White Paper

hello@bertin.fr — Thu, 13 Jun 2019 14:18:40 +0000

Microorganisms, like bacteria, fungi, archaea, algae, protozoa, and viruses, known as microbes, play a critical role in many different phenomena. They are involved in climate change, nutrient cycling, biodegradation and diseases. In biotechnology, microbes can be used in a wide range of fields, such as the pharmaceutical industry to produce drugs, the environmental sector to […]

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